Inflation pressure and lung vascular injury in preterm lambs.
نویسندگان
چکیده
CHEST / 105 / 3 / MARCH, 1994 / Supplement 115S 43 Long SE, Menon AS, Kato H, et al. Constant oxygen insufflation (COl) in a ventilatory failure model. Am Rev Respir Dis 1988; 138:630-35 44 Benditt J, Poliock M. Roa J, et al. Transtracheal delivery of gas decreases the oxygen cost of breathing. Am Rev Respir Dis 1993; 147:1207-10 45 Nahum A, Burke WC, Ravenscraft SA, et al. Lung mechanics and gas exchange during pressure controlled ventilation in dogs: augmentation of CO2 elimination by an intratracheal catheter. Am Rev Respir Dis 1992; 146:965-73 46 Burke WC, Nahum A, Ravenscraft SA, et al, Modes of tracheal gas insufflation: comparison of continuous and phase specific gas injection in normal dogs. Am Rev Respir Dis 1993 Am Rev Respir Dis 1993; 148:562-68 47 Nahum A, Ravenscraft SA, Nakos G, et al. Tracheal gas insufflation during pressure controlled ventilation: effect of catheter position, diameter, and flow rate. Am Rev Respir Dis 1992; 146:1411-18 48 Slutsky AS, Watson J, Leith DE, et at. Tracheal insufflation 02 (TRIO) at low flow rates sustains life for several hours, Anesthesiology 1985; 63:278-86 49 Isabey D, Boussignac C, Harf A. Effect of air entrainment on airway pressure during endotracheal gas injection. J AppI Physioi 1989; 67:771-79 50 Shutsky AS, Menon AS. Catheter position and blood gases during constant-flow ventiiation.J Appi Physiol 1987; 62:51319 51 Sznajder JI, Nahum A, Crawford GD, et at. Alveolar-pressure in homogeneity and gas exchange during constant flow ventihation in dogs. J Appi Physiol 1989; 67: 1489-94 52 Sznajder JI, Becker CJ, Crawford GP, et al. Combination of constant-flow and continuous positive-pressure ventilation in canine pulmonary edema. J Appi Physiol 1989; 67:817-23 53 Muller E, Kolobow T, Mandava 5, et al. On how to ventilate lungs as small as 12% of normal: intratracheal pulmonary ventilation (ITPV): a new mode of pulmonary ventilation
منابع مشابه
Pressure- versus volume-limited sustained inflations at resuscitation of premature newborn lambs
BACKGROUND Sustained inflations (SI) are advocated for the rapid establishment of FRC after birth in preterm and term infants requiring resuscitation. However, the most appropriate way to deliver a SI is poorly understood. We investigated whether a volume-limited SI improved the establishment of FRC and ventilation homogeneity and reduced lung inflammation/injury compared to a pressure-limited ...
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The interrelationship between the role of surfactant and a sustained inflation (SI) to aid ex utero transition of the preterm lung is unknown. We compared the effect of surfactant administered before and after an initial SI on gas exchange, lung mechanics, spatial distribution of ventilation, and lung injury in preterm lambs. Gestational-age lambs (127 days; 9 per group) received 100 mg/kg of a...
متن کاملPressure-limited sustained inflation vs. gradual tidal inflations for resuscitation in preterm lambs.
Support of the mechanically complex preterm lung needs to facilitate aeration while avoiding ventilation heterogeneities: whether to achieve this gradually or quickly remains unclear. We compared the effect of gradual vs. constant tidal inflations and a pressure-limited sustained inflation (SI) at birth on gas exchange, lung mechanics, gravity-dependent lung volume distribution, and lung injury...
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AIMS Preterm infants can be inadvertently exposed to high tidal volumes (V(T)) in the delivery room, causing lung inflammation and injury, but little is known about their effects on the brain. The aim of this study was to compare an initial 15 min of high V(T) resuscitation strategy to a less injurious resuscitation strategy on cerebral haemodynamics, inflammation and injury. METHODS Preterm ...
متن کاملVentilation-induced lung injury is not exacerbated by growth restriction in preterm lambs.
Intrauterine growth restriction (IUGR) and preterm birth are frequent comorbidities and, combined, increase the risk of adverse respiratory outcomes compared with that in appropriately grown (AG) infants. Potential underlying reasons for this increased respiratory morbidity in IUGR infants compared with AG infants include altered fetal lung development, fetal lung inflammation, increased respir...
متن کاملChronic lung injury in preterm lambs. Disordered respiratory tract development.
The cause of chronic lung disease of early infancy, often called bronchopulmonary dysplasia (BPD), remains unclear, partly because large-animal models that reliably reproduce BPD have not been available. We developed a model of BPD in lambs that are delivered prematurely and ventilated for 3 to 4 wk after birth to determine whether the histopathology of chronic lung injury in premature lambs mi...
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ورودعنوان ژورنال:
- Chest
دوره 105 3 Suppl شماره
صفحات -
تاریخ انتشار 1994